Why the study?
Does major abdominal surgery under balanced anaesthesia affect granulocyte microbicidal function in patients?
Does major abdominal surgery under balanced anaesthesia affect granulocyte microbicidal function in patients?
Microbicidal-related oxidative phagocytic functions of granulocytes are well maintained after major abdominal surgery under balanced anaesthesia.
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Postoperative neutrophil peroxidase activity rises without impairing phagocytosis; supports preserved microbicidal function after abdominal surgery but leaves open generalizability.
Granulocyte microbicidal functions were studied in 11 major abdominal surgery patients with the luminol-enhanced chemiluminescence method. The responses of granulocytes in phagocytosis of zymosan, S. aureus and E. coli and responses to N-formylmethionyl-leucylphenylalanine (FMLP) were unaffected by surgery. The percentage of high-peroxidase-activity cells among neutrophils was increased on postoperative days 1 (P less than 0.01) and 3-4 (P less than 0.05). We propose that microbicidal-related oxidative phagocytic functions of granulocytes are well maintained after major abdominal surgery under balanced anaesthesia.
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Perttilä et al. (1987) studied this question.
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