December 1, 1993Blood Coagulation & Fibrinolysis

The role of endotoxin immunity, neutrophil degranulation and contact activation in the pathogenesis of post-operative organ dysfunction

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Population

26 patients undergoing elective major surgery

Design

Cohort

Follow-up

24 hours post-surgery

Authors

MMMichael G. MythenUniversity College London GBG R BarclayEdinburgh Royal Infirmary GPG. PurdyShawnee State University

Discussion

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Implication

Higher IgG EndoCAb levels were associated with preserved gut perfusion; hypothesis-generating and should not yet change perioperative practice.

Structured PICO

Population

26 patients undergoing elective major surgery

Outcome

Development of gut mucosal hypoperfusion (pHi < 7.32) and changes in endotoxin core antibodies (EndoCAb), neutrophil elastase alpha-1 antitrypsin complexes (NE), and contact system componentssurrogate

High baseline levels of anti-endotoxin antibodies may protect against endotoxin-induced contact activation and gut mucosal hypoperfusion during major surgery, potentially reducing the risk of post-operative multiple organ failure.

Cite This Study

Mythen et al. (1993) studied this question.

synapsesocial.com/papers/6a71b21cac440176ef2a4b2c https://doi.org/10.1097/00001721-199312000-00016

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Implication

Higher IgG EndoCAb levels were associated with preserved gut perfusion; hypothesis-generating and should not yet change perioperative practice.

The role of endotoxin immunity, neutrophil degranulation and contact activation in the pathogenesis of post-operative organ dysfunction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The role of endotoxin immunity, neutrophil degranulation and contact activation in the pathogenesis of post-operative organ dysfunction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider