Why the study?
Does major surgery alter neutrophil superoxide and leukotriene production in patients?
Population
28 patients who underwent major surgery
Comparison
Major surgery vs Pre-operative baseline
Design
Cohort
Follow-up
postoperative period
Authors
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Postoperative neutrophil changes may heighten infection risk; hypothesis-generating and requires prospective validation before clinical adoption.
Does major surgery alter neutrophil superoxide and leukotriene production in patients?
Major surgery alters neutrophil function by decreasing superoxide production and increasing leukotriene A4 production in the postoperative period.
Utoh et al. (1988) studied this question.
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