December 13, 2007AJP Regulatory Integrative and Comparative Physiology

Inhibition of shortening velocity of skinned skeletal muscle fibers in conditions that mimic fatigue

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Population

Permeable rabbit psoas fibers

Comparison

Conditions mimicking fatigue: high myosin… vs Control conditions: low myosin RLC…

Design

Preclinical

Authors

CKChristina KaratzaferiUniversity of Thessaly KFKathleen E. Franks-SkibaQB3 RCRoger CookeAmerican College of Cardiology

Discussion

Member takes

Implication

Does not support clinical changes in fatigue management; leaves open translation of synergy to human muscle.

Structured PICO

Population

Permeable rabbit psoas fibers

Intervention

Conditions mimicking fatigue: high myosin regulatory light chain (RLC) phosphorylation (>50%), low pH (6.2), and high phosphate (30 mM)

Comparator

Control conditions: low myosin RLC phosphorylation (10%), pH 7, and phosphate 5 mM

Outcome

Shortening velocity of muscle fiberssurrogate

In conditions simulating physiological muscle fatigue, myosin phosphorylation, low pH, and high phosphate synergistically inhibit contraction velocity of fully activated fast muscle fibers.

Cite This Study

Karatzaferi et al. (2007) studied this question.

synapsesocial.com/papers/6a8e6d8ffb6e86649d28d899 https://doi.org/10.1152/ajpregu.00541.2007

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Inhibition of shortening velocity of skinned skeletal muscle fibers in conditions that mimic fatigue

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of shortening velocity of skinned skeletal muscle fibers in conditions that mimic fatigue

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider