Why the study?
Does myosin light chain phosphorylation inhibit muscle fiber shortening velocity in the presence of vanadate?
Population
Muscle fibers
Comparison
Myosin light chain phosphorylation in the… vs Dephosphorylated muscle fibers
Design
Preclinical
Authors
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May inform mechanisms of muscle fatigue in prepower-stroke states; leaves open translation to human cardiac physiology.
Does myosin light chain phosphorylation inhibit muscle fiber shortening velocity in the presence of vanadate?
Myosin phosphorylation can inhibit shortening velocity in muscle fibers with large populations of myosin heads trapped in prepower stroke states, which may have implications for understanding muscle fatigue.
Franks-Skiba et al. (2006) studied this question.
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