Why the study?
Does a molded autologous pericardial aortic valve prosthesis with single point attached commissures (SPAC) provide reliable valve competence and low transvalvular gradients in a sheep model?
Population
10 sheep undergoing aortic valve replacement
Design
Preclinical
Follow-up
6 to 11 months
Authors
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Does not support clinical use; leaves open translation of SPAC autologous pericardial valves to human aortic replacement.
Does a molded autologous pericardial aortic valve prosthesis with single point attached commissures (SPAC) provide reliable valve competence and low transvalvular gradients in a sheep model?
A novel stentless molded autologous pericardial aortic valve with single point attached commissures demonstrated good pliability, anchoring, and low transvalvular gradients in a sheep model up to 11 months.
Goetz et al. (2008) studied this question.
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