What question did this study set out to answer?

To review existing clinical guidelines and present a practical management framework for cardiotoxicity associated with targeted anticancer agents and angiogenesis inhibitors.

May 1, 2016Journal of Cardiovascular MedicineOpen Access

A recommended practical approach to the management of target therapy and angiogenesis inhibitors cardiotoxicity

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To review existing clinical guidelines and present a practical management framework for cardiotoxicity associated with targeted anticancer agents and angiogenesis inhibitors.
Reviewed guideline-recommended strategies for diagnosing and managing cardiotoxicity in cancer patients receiving targeted therapies.
Assessed cardiovascular toxicity profiles across major drug classes, including anti-HER2 agents, angiogenesis inhibitors, BCR-ABL inhibitors, and proteasome inhibitors.
Anti-epidermal growth factor receptor 2 (HER2) therapies primarily induce left ventricular systolic dysfunction and clinical heart failure.
Angiogenesis inhibitors are frequently linked to hypertension, left ventricular dysfunction, myocardial ischemia, QT interval prolongation, and arterial or venous thrombosis.

Structured PICO

Population

Patients under anticancer target therapy (including epidermal growth factor receptor 2 inhibitors, angiogenic inhibitors, directed Abelson murine leukemia viral oncogene homolog inhibitors, and proteasome inhibitors)

Intervention

Guideline-based practical approach for the management of cardiotoxicity

This review summarizes guideline-based practical approaches for managing cardiotoxicity associated with targeted anticancer therapies.

Discussion

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Implication

Offers clinicians a consolidated cardiotoxicity management approach; extends guideline summaries but leaves open prospective validation.

Cite This Study

Maurea et al. (2016) studied this question.

synapsesocial.com/papers/6a8e87b536b488c1e27d836e https://doi.org/10.2459/jcm.0000000000000383

Topics

Cardio-oncology

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A recommended practical approach to the management of target therapy and angiogenesis inhibitors cardiotoxicity

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

A recommended practical approach to the management of target therapy and angiogenesis inhibitors cardiotoxicity

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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