July 1, 2000Experimental Physiology

Absence of reflex vascular responses from the intrapulmonary circulation in anaesthetised dogs

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Population

Dogs anesthetized with α-chloralose, artificially ventilated, with cardiopulmonary bypass established and…

Design

Preclinical

Authors

NMN. C. McMahonGlaxoSmithKline (United Kingdom)MDMark J. DrinkhillUniversity of Leeds DMDavid S. MyersRutgers, The State University of New Jersey

Discussion

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Implication

Does not elicit consistent systemic or limb vasoconstriction in anesthetized dogs; leaves open relevance to human pulmonary hypertension.

Structured PICO

Population

Dogs anesthetized with α-chloralose, artificially ventilated, with cardiopulmonary bypass established and isolated intrapulmonary region of the left lung.

Intervention

Localized distension of the intrapulmonary arterial and venous circulations (increasing intrapulmonary arterial pressure from 14 ± 1 to 43 ± 3 mmHg or venous pressure from 5 ± 2 to 34 ± 2 mmHg).

Outcome

Changes in systemic or limb vascular resistancessurrogate

Increases in pressure confined to the intrapulmonary arterial and venous circulations do not cause consistent reflex vascular responses in anesthetized dogs.

Cite This Study

McMahon et al. (2000) studied this question.

synapsesocial.com/papers/6a8e98910f86ea2c3a3bdb13 https://doi.org/10.1017/s0958067000019461

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Absence of reflex vascular responses from the intrapulmonary circulation in anaesthetised dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Absence of reflex vascular responses from the intrapulmonary circulation in anaesthetised dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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