CACA Guidelines for holistic integrative assessment (2025)

The complexity and heterogeneity of malignant tumors necessitate a paradigm shift from a disease-centric to a patient-centric model of care. Cancer holistic integrative assessment (CHIA) is a multidimensional evaluation process that forms the cornerstone of personalized oncology. CHIA is characterized by four core principles: integrative philosophy, multidimensionality, dynamic individualization, and multidisciplinary collaboration. Key assessment domains include: 1) General status (performance status, physical function, nutrition); 2) Symptom burden ( pain, fatigue, et al.); 3) Organ function and comorbidities to gauge treatment tolerance; 4) Psychological and cognitive state (distress, anxiety, depression, cognitive function); 5) Family and social support systems, including financial toxicity; 6) Tumor biology (stage, molecular profile) to define therapeutic goals; and 7) Genetic risk 8)fertility preservation needs 9) Traditional Chinese Medicine Tumor Pathogenesis Identification and Evaluation. CHIA is a pivotal, dynamic process essential for tailoring safe, effective, and humanistic anticancer therapy. Its systematic implementation, supported by training, standardized protocols, and digital tools, is fundamental to advancing precision oncology and achieving the strategic goal of "Healthy China."