March 1, 1999EndocrinologyOpen Access

Activation of the Mitogen-Activated Protein Kinase Cascade Is Necessary But Not Sufficient for Basic Fibroblast Growth Factor- and Epidermal Growth Factor-Stimulated Expression of Endothelial Nitric Oxide Synthase in Ovine Fetoplacental Artery Endothelial Cells*

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Population

Ovine fetoplacental artery endothelial cells

Design

Preclinical

Follow-up

24 hours

Authors

JZJing ZhengFujian Medical University IBIan M. BirdJohns Hopkins University Applied Physics Laboratory AMAmy N. MelsaetherMotif BioSciences (United States)

Discussion

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Implication

MAPK necessary but not sufficient for bFGF/EGF-induced eNOS expression in fetoplacental endothelium; leaves open human translational relevance.

Structured PICO

Population

Ovine fetoplacental artery endothelial cells

Intervention

Basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) at 10 ng/ml, with or without PD 98059 (MAPK kinase inhibitor)

Outcome

Endothelial nitric oxide synthase (eNOS) protein expression and MAPK activationsurrogate

Activation of the MAPK cascade is necessary but not sufficient for bFGF- and EGF-induced increases in eNOS protein expression in ovine fetoplacental artery endothelial cells.

Cite This Study

Zheng et al. (1999) studied this question.

synapsesocial.com/papers/6a8ea361af8fd2d347938462 https://doi.org/10.1210/endo.140.3.6542

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Implication

MAPK necessary but not sufficient for bFGF/EGF-induced eNOS expression in fetoplacental endothelium; leaves open human translational relevance.

Activation of the Mitogen-Activated Protein Kinase Cascade Is Necessary But Not Sufficient for Basic Fibroblast Growth Factor- and Epidermal Growth Factor-Stimulated Expression of Endothelial Nitric Oxide Synthase in Ovine Fetoplacental Artery Endothelial Cells*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activation of the Mitogen-Activated Protein Kinase Cascade Is Necessary But Not Sufficient for Basic Fibroblast Growth Factor- and Epidermal Growth Factor-Stimulated Expression of Endothelial Nitric Oxide Synthase in Ovine Fetoplacental Artery Endothelial Cells*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider