Key result
Shear stress induced rapid eNOS phosphorylation on Ser1177 in ovine fetoplacental artery endothelial cells through a PI-3K-dependent pathway.
Population
Ovine fetoplacental artery endothelial (OFPAE) cells
Comparison
Pulsatile shear stress and/or basic fibroblast… vs Static culture or low shear stress (3 dynes/cm2)
Design
Preclinical
Authors
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Hypothesis-generating for placental endothelial signaling; leaves open translation to human pregnancy disorders and should not yet change practice.
Shear stress induces rapid eNOS phosphorylation in ovine fetoplacental artery endothelial cells via a PI-3K-dependent pathway, distinct from the mechanisms regulating prolonged eNOS protein expression.
Li et al. (2004) studied this question. Shear stress vs. Static culture / 3 dynes/cm2 shear stress was evaluated on eNOS phosphorylation and protein expression. Shear stress induced rapid eNOS phosphorylation on Ser1177 in ovine fetoplacental artery endothelial cells through a PI-3K-dependent pathway.
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