Key result
Shear stress stimulates eNOS phosphorylation at Ser(635) via a PKA-dependent but PI3K-independent pathway, suggesting a role in chronic regulation of eNOS.
Population
Bovine aortic endothelial cells (BAEC)
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for chronic shear effects on endothelium.
Shear stress stimulates eNOS phosphorylation at Ser(635) via a PKA-dependent but PI3K-independent pathway, suggesting a role in chronic regulation of eNOS.
Boo et al. (2002) studied this question. Shear stress, VEGF, and 8-BRcAMP was evaluated on Phosphorylation of eNOS at Ser(635), Thr(497), and Ser(116). Shear stress stimulates eNOS phosphorylation at Ser(635) via a PKA-dependent but PI3K-independent pathway, suggesting a role in chronic regulation of eNOS.
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