Key result
Exposure of ovine fetoplacental artery endothelial cells to 25 dynes/cm2 shear stress increased NO production 8-fold, eNOS protein 3.6-fold, and eNOS mRNA 1.5-fold (P < 0.05).
Population
Ovine fetoplacental artery endothelial (OFPAE) cells grown in artificial capillary modules
Comparison
Exposure to pulsatile shear stress at 10, 15, or… vs Baseline shear stress at 3 dynes/cm2
Design
Preclinical
Follow-up
up to 24 h
Authors
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Shear stress may regulate ovine placental NO signaling; leaves open human relevance and in vivo confirmation.
p-value: p=< 0.05
Pulsatile shear stress increases NO production and eNOS expression in ovine fetoplacental artery endothelial cells, providing a potential mechanism for increased placental blood flow during pregnancy.
Li et al. (2003) studied this question. Pulsatile shear stress vs. 3 dynes/cm2 was evaluated on Nitric oxide (NO) production and endothelial cell nitric oxide synthase (eNOS) expression (p=< 0.05). Exposure of ovine fetoplacental artery endothelial cells to 25 dynes/cm2 shear stress increased NO production 8-fold, eNOS protein 3.6-fold, and eNOS mRNA 1.5-fold (P < 0.05).
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