Population
Pulmonary arterial endothelial cells (PAEC) isolated from fetal lambs and adult sheep
Comparison
Fluid shear stress for 8 hours vs Static conditions (no shear stress)
Design
Preclinical
Follow-up
8 hours
Authors
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May inform fetal pulmonary vascular adaptation studies; leaves open human translation and AP-1 targeting.
Shear stress-induced eNOS expression in the pulmonary arterial circulation is developmentally regulated, relying on AP-1 activation specifically in fetal cells.
Wedgwood et al. (2003) studied this question.
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