Key result
Fluid shear stress induced a significantly greater release of nitric oxide in adult (890 +/- 140 nmol NO x min x cm(-2)) than in fetal (300 +/- 40) carotid arteries.
Population
Intact 4-cm carotid artery segments taken from term fetal lambs and nonpregnant adult sheep
Comparison
Fluid shear stress and maximal endothelial… vs Fetal lamb carotid arteries versus nonpregnant…
Design
Preclinical
Authors
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Hypothesis-generating for age-dependent endothelial NO responses; leaves open translation to human vascular development or disease.
Absolute Event Rate: 890% vs 300%
Maturational increases in endothelial vasodilator capacity are driven by enhanced eNOS-specific activity and more efficient coupling to activating stimuli, rather than increased eNOS expression.
White et al. (2005) studied this question. Maturation (adult vs fetal) vs. Fetal carotid arteries was evaluated on Nitric oxide (NO) release induced by fluid shear stress (in nmol NO x min x cm(-2)). Fluid shear stress induced a significantly greater release of nitric oxide in adult (890 +/- 140 nmol NO x min x cm(-2)) than in fetal (300 +/- 40) carotid arteries.
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