Why the study?
Does maturation alter NO-induced relaxation and cyclic nucleotide responses in ovine cerebral arteries?
Does maturation alter NO-induced relaxation and cyclic nucleotide responses in ovine cerebral arteries?
Maturation slows the mechanisms mediating NO-induced relaxation in ovine cerebral arteries, emphasizing that cerebrovascular effects of NO are highly age-dependent and artery-specific.
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Greater NO efficacy in newborn cerebral arteries cautions against age-uniform dosing; leaves open human translation.
Nauli et al. (2003) studied this question.
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