What does this research mean for the field?

In adults with A(H1N1)pdm09-related pneumonia, age over 60, comorbidities, and organ dysfunction are strong independent predictors of ICU admission, and intensified antiviral therapy does not improve mortality outcomes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess the burden, clinical predictors, and outcomes associated with ICU admission and mortality among hospitalized adults with influenza A(H1N1)pdm09-related pneumonia.

August 26, 2026PLoS ONEOpen Access

ICU admission and mortality in adult patients with influenza A(H1N1)pdm09-related pneumonia in Vietnam since the 2009 H1N1 pandemic: A 10-year cohort study

View Full Paper

Ask AI

Bookmark

Authors

QHQuang Minh Ho BDBích Thủy Dương LNLe Nhu Tung Nguyen

Discussion

Member takes

Implication

Retrospective cohort study reveals high ICU admission rates and clinical predictors of mortality in adults with influenza A(H1N1)pdm09 pneumonia, highlighting the need for targeted critical care.

Key Points

To assess the burden, clinical predictors, and outcomes associated with ICU admission and mortality among hospitalized adults with influenza A(H1N1)pdm09-related pneumonia.
Retrospectively analyzed medical records of adults (N=729) hospitalized with laboratory-confirmed influenza A(H1N1)pdm09 infection between 2009 and 2019 at a tertiary infectious diseases hospital in Vietnam.
Evaluated clinical characteristics, organ dysfunction markers, antiviral regimens, and outcomes among patients with confirmed pneumonia (n=158).
Among 158 patients with pneumonia, 36.7% developed moderate-to-severe ARDS, 48.7% were admitted to the ICU, 15.2% required invasive ventilation, and 8.2% died.
Age older than 60 years (AOR 18.91, 95% CI 3.60–99.24), presence of comorbidities (AOR 9.39, 95% CI 2.75–32.06), and systemic inflammation were independent predictors of ICU admission.
Invasive mechanical ventilation (AOR 8.426, 95% CI 1.105–141.366, P=0.039) and intensified antiviral therapy (AOR 8.577, 95% CI 1.416–83.341, P=0.020) were independently associated with mortality.

Cite This Study

Ho et al. (2026) studied this question.

synapsesocial.com/papers/6a8ebb54451774b83f3b4cdd https://doi.org/10.1371/journal.pone.0348450

View Full Paper

Ask AI

Bookmark

Implication

Retrospective cohort study reveals high ICU admission rates and clinical predictors of mortality in adults with influenza A(H1N1)pdm09 pneumonia, highlighting the need for targeted critical care.

ICU admission and mortality in adult patients with influenza A(H1N1)pdm09-related pneumonia in Vietnam since the 2009 H1N1 pandemic: A 10-year cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

ICU admission and mortality in adult patients with influenza A(H1N1)pdm09-related pneumonia in Vietnam since the 2009 H1N1 pandemic: A 10-year cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider