What question did this study set out to answer?

To describe the clinical and epidemiological characteristics of the first cohort of adult patients admitted to the intensive care unit with severe respiratory failure caused by influenza A (H1N1)v in Spain.

September 11, 2009Critical CareOpen Access

Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain

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Authors

JRJordi RelloInstituto de Salud Carlos III ARAlejandro RodríguezBrigham Young University PIPedro IbañezUniversidad de Salamanca

Discussion

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Implication

Observational study reports high rates of multiorgan dysfunction and mechanical ventilation in young adults with severe H1N1 infection, highlighting risks in obesity and pregnancy.

Key Points

To describe the clinical and epidemiological characteristics of the first cohort of adult patients admitted to the intensive care unit with severe respiratory failure caused by influenza A (H1N1)v in Spain.
Conducted a retrospective medical chart review using standardized reporting forms across intensive care units in Spain.
Identified N=32 adult patients with influenza A (H1N1)v infection confirmed via real-time reverse transcriptase-polymerase-chain-reaction (RT-PCR) assays between June 23 and July 31, 2009.
Among 32 patients (median age 36 years; 31.2% obese, 6.3% pregnant), primary viral pneumonitis was diagnosed in 90.6% (n=29), multiorgan dysfunction in 75.0% (n=24), and invasive mechanical ventilation was required in 75.0% (n=24).
Renal replacement techniques were needed in 21.9% (n=7), with 6 patients dying within 28 days (18.8%) and 2 subsequent late deaths, resulting in an overall mortality of 25.0% (8 of 32).
Oseltamivir therapy was initiated 2 to 8 days following illness onset, with 31.2% receiving high-dose regimens (300 mg/day) across a mean duration of 8.0 ± 3.3 days.

Cite This Study

Rello et al. (2009) studied this question.

synapsesocial.com/papers/6a7d1f332f2f9d79738b20cc https://doi.org/10.1186/cc8044

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Implication

Observational study reports high rates of multiorgan dysfunction and mechanical ventilation in young adults with severe H1N1 infection, highlighting risks in obesity and pregnancy.

Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain

Discussion

Member takes

Implication

Key Points

Cite This Study

Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain

Discussion

Member takes

Implication

Key Points

Cite This Study

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