Key result
Patients with repaired tetralogy of Fallot and preserved LVEF showed significantly decreased basilar LV peak circumferential strain compared to healthy volunteers (-15.6% vs. -17.6%; P<0.01).
Why the study?
Does magnetic resonance imaging detect early regional left ventricular dysfunction in patients with repaired tetralogy of Fallot and pulmonary regurgitation compared to healthy volunteers?
Case-Control (n=28)
Does magnetic resonance imaging detect early regional left ventricular dysfunction in patients with repaired tetralogy of Fallot and pulmonary regurgitation compared to healthy volunteers?
Absolute Event Rate: -15.6% vs -17.6%
p-value: p=< 0.01
MRI tagging can detect early regional LV dysfunction, such as impaired circumferential strain and delayed rotation, in patients with repaired tetralogy of Fallot despite preserved global LVEF.
Supports MRI detection of subclinical LV dysfunction in repaired tetralogy of Fallot despite preserved LVEF; hypothesis-generating and requires prospective validation before practice change.
PURPOSE: To test the potential of magnetic resonance imaging (MRI) in early detection of left ventricular (LV) dysfunction in patients with pulmonary regurgitation and normal LV ejection fraction after repair of tetralogy of Fallot. MATERIALS AND METHODS: Patients (n = 18) with repaired tetralogy of Fallot and pulmonary regurgitation were prospectively recruited. Healthy volunteers (n = 10) were used as control. Tagging MR images were acquired at the base, mid, and apical LV levels for assessing segmental rotation and circumferential strain. Cine MR images and velocity-encoded MR images were also acquired for assessment of biventricular volumes and biventricular function and pulmonary regurgitant fraction, respectively. Mean values were compared between groups using unpaired Student's t-test. RESULTS: Patients presented with preserved global LV function (LVEF of 59 ± 5%). A significant decrease in LV peak circumferential strain was seen in patients compared with normal volunteers at the basilar (-15.6 ± 4.5% vs. -17.6 ± 4.4%; P < 0.01) and apical (-14.4± 6.1% vs. -17.3± 5.1%, P < 0.01) slices. LV peak rotation was also delayed in patients compared with volunteers at the basilar (6.1 ± 2.6° vs. 4.2 ± 0.6°; P < 0.01) and mid (8.0 ± 1.7° vs. 4.9 ± 1.0°; P < 0.01) slices. CONCLUSION: MRI can detect early regional LV dysfunction in patients with preserved LVEF after repair of tetralogy of Fallot. MR may be a useful technique for guiding clinical decisions in these patients in order to prevent future global LV deterioration.
No takes yet. Share an insight, caveat, or question.
Ordovás et al. (2011) conducted a case-control in Repaired tetralogy of Fallot (n=28). Repaired tetralogy of Fallot with pulmonary regurgitation vs. Healthy volunteers was evaluated on LV peak circumferential strain at the basilar slice (p=< 0.01). Patients with repaired tetralogy of Fallot and preserved LVEF showed significantly decreased basilar LV peak circumferential strain compared to healthy volunteers (-15.6% vs. -17.6%; P<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: