Key result
Synthetic atrial natriuretic peptide (ANP 8-33) decreased cardiac output in anesthetized dogs at both nonhypotensive and hypotensive concentrations without causing coronary vasoconstriction.
Population
Isolated, Langendorff-perfused rat hearts and anesthetized dogs
Design
Preclinical
Authors
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Hypothesis-generating in dogs; leaves open human hemodynamic effects and precludes practice change.
In animal models, atrial natriuretic peptide decreases cardiac output without causing coronary vasoconstriction.
Burnett et al. (1987) studied this question. Synthetic atrial natriuretic peptide (ANP 8-33) was evaluated on Coronary flow dynamics and cardiac output. Synthetic atrial natriuretic peptide (ANP 8-33) decreased cardiac output in anesthetized dogs at both nonhypotensive and hypotensive concentrations without causing coronary vasoconstriction.
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