What question did this study set out to answer?

The aim was to determine the effects of synthetic alpha-human ANP on the coronary circulation in subjects with normal coronary arteries.

January 1, 1991Japanese Circulation JournalOpen Access

Effects of synthetic human atrial natriuretic peptide on the human coronary circulation in subjects with normal coronary arteries.

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Why the study?

Does intravenous synthetic alpha-human ANP improve coronary circulation in subjects with normal coronary arteries?

Population

15 subjects with normal coronary arteries and normal ventricular function

Design

Other

Follow-up

15 minutes

Authors

KEK. EgashiraKyushu University TIT InouToyama University Hospital TITsutomu ImaizumiGeneral / Preventive / Lipids

Discussion

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Implication

ANP coronary effects in normals support further investigation; leaves open therapeutic translation in CAD without randomized data.

Key Points

The aim was to determine the effects of synthetic alpha-human ANP on the coronary circulation in subjects with normal coronary arteries.
Evaluated the epicardial coronary arterial diameter using selective coronary arteriography.
Estimated coronary blood flow with a subselective intracoronary Doppler catheter.
Administered ANP at 0.03 micrograms/min/kg intravenously over 15 minutes.
ANP caused significant dilation of the proximal left anterior descending artery (from 2.6 +/- 0.4 mm to 3.1 +/- 0.5 mm, p < 0.01).
Mean arterial pressure decreased from 89 +/- 5 mmHg to 83 +/- 5 mmHg (p < 0.01) after ANP infusion.
Estimated coronary blood flow significantly increased, indicating reduced coronary vascular resistance (p < 0.01).

Structured PICO

Does intravenous synthetic alpha-human ANP improve coronary circulation in subjects with normal coronary arteries?

Population

15 subjects with normal coronary arteries and normal ventricular function

Intervention

Synthetic alpha-human atrial natriuretic peptide (ANP) 0.03 micrograms/min/kg given intravenously over 15 minutes

Outcome

Epicardial coronary arterial diameter and coronary blood flowsurrogate

Intravenous infusion of a clinical dose of ANP dilates both large epicardial and small resistance coronary vessels in humans with normal coronary arteries.

Cite This Study

Egashira et al. (1991) studied this question.

synapsesocial.com/papers/6a2098668b0daa6b96cd29c5 https://doi.org/10.1253/jcj.55.1050

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Effects of synthetic human atrial natriuretic peptide on the human coronary circulation in subjects with normal coronary arteries.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of synthetic human atrial natriuretic peptide on the human coronary circulation in subjects with normal coronary arteries.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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