Key result
Female rats exposed to a high fat diet showed higher expression of proteins involved in thermogenesis and fat oxidation and lower expression of fat synthesis proteins compared to male rats.
Why the study?
Does gender affect the proteomic profile of brown adipose tissue in rats exposed to a high fat diet?
Population
Male and female rats (lean and obese)
Comparison
High fat diet (HFD) vs Between genders (male vs female)
Design
Preclinical
Authors
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Supports sex-dimorphic BAT responses to HFD in rats; hypothesis-generating for human obesity research.
Does gender affect the proteomic profile of brown adipose tissue in rats exposed to a high fat diet?
Female rats show a more favorable brown adipose tissue proteomic profile for thermogenesis and fat oxidation in response to a high-fat diet compared to male rats.
Choi et al. (2011) studied Obesity. High fat diet vs. Male rats was evaluated on Differential proteome analysis of brown adipose tissue. Female rats exposed to a high fat diet showed higher expression of proteins involved in thermogenesis and fat oxidation and lower expression of fat synthesis proteins compared to male rats.
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