Key result
Brown adipose tissue activity was associated with gender-specific brain glucose metabolism, with females showing richer hypermetabolic regions compared to smaller, dispersed networks in males.
Why the study?
Thermogenesis of brown adipose tissue (BAT) is controlled by central modulating mechanisms, but changes in brain metabolism of BAT-positive subjects of different genders remain unclear.
Are there gender differences in regional cerebral glucose metabolic activity associated with brown adipose tissue (BAT) activities?
Population
26 BAT-positive and 26 BAT-negative healthy subjects, including males, females, and postmenopausal females
Comparison
BAT-positive vs BAT-negative subjects across genders and menopausal status
Design
Brain fluorodeoxyglucose (FDG)-PET imaging study
Authors
Loading...
Gender-specific BAT-brain metabolic associations are hypothesis-generating; should not change practice pending prospective validation.
Observational (n=52)
Are there gender differences in regional cerebral glucose metabolic activity associated with brown adipose tissue (BAT) activities?
BAT-related brain functional networks differ significantly between males and females, potentially related to sex hormones.
Shao et al. (2020) conducted an observational in Healthy subjects (n=52). Brown adipose tissue (BAT) activity vs. BAT-negative subjects was evaluated on Regional cerebral glucose metabolic activity. Brown adipose tissue activity was associated with gender-specific brain glucose metabolism, with females showing richer hypermetabolic regions compared to smaller, dispersed networks in males.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: