Key result
Modifications of antiviral defence altered TTV and TLMV viremia, with immunosuppressants increasing viral titers and interferon treatment causing a temporary decrease.
Why the study?
How do modifications of antiviral defence affect TT virus (TTV) and TTV-like mini virus (TLMV) viremia?
Observational
How do modifications of antiviral defence affect TT virus (TTV) and TTV-like mini virus (TLMV) viremia?
Immune modulation, such as immunosuppression or interferon treatment, directly influences the viremia levels of chronically replicating TTV and TLMV.
Immune modulation was associated with TTV/TLMV viremia shifts; leaves open their utility as antiviral defence markers pending prospective validation.
The present study was designed to investigate how two chronically replicating viruses, TT virus (TTV) and TTV-like mini virus (TLMV), interact with host defence systems. Successive serum samples from three groups of subjects, undergoing modifications of their antiviral defence, were tested by real-time PCR to measure changes in viral titers, and by sequence analyses to indicate whether increases in viremia could be attributed to infection with an unfamiliar strain: 1) in patients receiving immunosuppressants subsequent to kidney transplantation, viral titers tended to increase; 2) in soldiers undergoing extreme training known to cause immunosuppression, insignificant increases in titers were observed; and 3) interferon treatment of patients with hepatitis C virus caused a temporary decrease in TTV and TLMV titers. Increases in viremia were associated only occasionally with the appearance of novel strains. The above results add to knowledge on how these viruses are influenced by the host.
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Moen et al. (2003) conducted an observational in TTV and TLMV viremia. Modifications of antiviral defence (immunosuppressants, extreme training, interferon) was evaluated on Changes in TTV and TLMV viral titers. Modifications of antiviral defence altered TTV and TLMV viremia, with immunosuppressants increasing viral titers and interferon treatment causing a temporary decrease.
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