Key result
The N-terminal sequence (residues 1-38) and the ankyrin repeats of MYPT1 are involved in binding and activating the catalytic subunit of type 1 protein phosphatase.
The N-terminal sequence and ankyrin repeats of MYPT1 are critical for binding and activating the catalytic subunit of type 1 protein phosphatase.
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Animal data map MYPT1 domains in phosphatase regulation; leaves open human cardiovascular translation.
Tanaka et al. (1998) studied this question. MYPT1 fragments was evaluated on Binding and activation of PP1c. The N-terminal sequence (residues 1-38) and the ankyrin repeats of MYPT1 are involved in binding and activating the catalytic subunit of type 1 protein phosphatase.
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