Population
Smooth muscle myosin phosphatase holoenzyme, type 1 phosphatase catalytic subunit, myosin, heavy meromyosin…
Comparison
Recombinant proteins representing the N-terminal… vs PP1c alone
Design
Preclinical
Authors
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Hypothesis-generating for smooth muscle phosphatase regulation; requires validation in intact models before translational relevance.
This basic science study demonstrates that the N-terminal portion of the large subunit of smooth muscle myosin phosphatase is responsible for binding to phosphorylated light chains and the catalytic subunit, thereby modulating its kinetic activity.
Ichikawa et al. (1996) studied this question.
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