Key result
Smooth-muscle myosin phosphatase is a heterotrimer where regulatory subunits target the catalytic subunit (PP1 beta) to specific substrates, determining its specificity and subcellular location.
The specificity and subcellular location of protein phosphatase-1 are determined by its interaction with specific targeting subunits, explaining the distinctive properties of smooth and skeletal muscle myosin phosphatases.
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Reveals heterotrimeric myosin phosphatase structure; extends molecular understanding of smooth-muscle regulation but leaves clinical translation open.
Alessi et al. (1992) studied this question. Smooth-muscle myosin phosphatase is a heterotrimer where regulatory subunits target the catalytic subunit (PP1 beta) to specific substrates, determining its specificity and subcellular location.
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