Key result
Patients with an abnormal relaxation pattern showed augmented left atrial reservoir function (ARV/SV 0.73 vs 0.61, p<0.05), whereas those with a pseudonormal pattern showed deteriorated function.
Why the study?
Does the functional volume change curve derived from Doppler flow spectra reveal differences in left atrial reservoir and booster pump function among patients with normal, abnormal, and pseudonormal left ventricular diastolic function?
Cross-Sectional (n=110)
Does the functional volume change curve derived from Doppler flow spectra reveal differences in left atrial reservoir and booster pump function among patients with normal, abnormal, and pseudonormal left ventricular diastolic function?
Absolute Event Rate: 0.73% vs 0.61%
p-value: p=<0.05
A novel Doppler-derived functional volume change curve demonstrates that left atrial reservoir and booster pump functions are augmented in abnormal LV relaxation but deteriorated in pseudonormal filling, suggesting vulnerability to pulmonary congestion in the latter.
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May indicate congestion vulnerability in pseudonormal filling; hypothesis-generating for Doppler LA assessment in diastolic dysfunction.
Nakao et al. (2001) conducted a cross-sectional in Left ventricular diastolic dysfunction (n=110). Abnormal left ventricular diastolic function vs. Normal left ventricular diastolic function was evaluated on Atrial reservoir volume to stroke volume ratio (ARV/SV) (p=<0.05). Patients with an abnormal relaxation pattern showed augmented left atrial reservoir function (ARV/SV 0.73 vs 0.61, p<0.05), whereas those with a pseudonormal pattern showed deteriorated function.
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