Key result
Ectopic renin from pulmonary and paraovarian tumors is similar to the renal enzyme and can be secreted in an inactive form, with slight molecular weight differences between active and inactive forms.
Population
Two malignant renin-secreting tumors (pulmonary and paraovarian)
Design
Preclinical
Authors
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Animal data on tumoral renin should not alter practice; leaves open its role in human hypertension.
Ectopic tumoral renin is similar to the renal enzyme and can be secreted in an inactive form, supporting the hypothesis of an inactive initial state of renin.
Soubrier et al. (1982) studied Malignant renin-secreting tumors (n=2). Tumoral extracts was evaluated on Renin activity and molecular weight. Ectopic renin from pulmonary and paraovarian tumors is similar to the renal enzyme and can be secreted in an inactive form, with slight molecular weight differences between active and inactive forms.