Key result
Rapid ventricular pacing in rabbits produced chronic biventricular congestive heart failure, significantly increasing left ventricular end diastolic pressure (19.3 vs -0.6 mm Hg, p<0.01).
Absolute Event Rate: 19.3% vs -0.6%
p-value: p=<0.01
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Validates rapid ventricular pacing as a chronic HF model in rabbits; leaves open translation to human therapeutics.
Masaki et al. (1993) studied Congestive heart failure model. Rapid ventricular pacing vs. Sham operation (not paced) was evaluated on Left ventricular end diastolic pressure (mm Hg) (p=<0.01). Rapid ventricular pacing in rabbits produced chronic biventricular congestive heart failure, significantly increasing left ventricular end diastolic pressure (19.3 vs -0.6 mm Hg, p<0.01).
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