Key result
The 4-oxoquinoline derivative 4h reduced Bovine Herpesvirus Type 5 production by ≥80% in vitro, demonstrating a more prominent antiviral effect than acyclovir.
Why the study?
Bovine herpesvirus type 5 causes meningoencephalitis in cattle, and oxoquinoline derivatives have emerged as an important focus in antiviral drug research.
Do synthetic 4-oxoquinoline derivatives inhibit Bovine herpesvirus type 5 replication in vitro?
Do synthetic 4-oxoquinoline derivatives inhibit Bovine herpesvirus type 5 replication in vitro?
The 4-oxoquinoline derivative 4h demonstrates promising in vitro antiviral activity against Bovine herpesvirus type 5, outperforming acyclovir.
Identifies a promising non-nucleoside candidate for herpesvirus treatment; leaves open whether these in.
BACKGROUND: Bovine herpesvirus type 5 is an important agent of meningoencephalitis in cattle and has been identified in outbreaks of bovine neurological disease in several Brazilian states. In recent years, oxoquinoline derivatives have become an important focus in antiviral drug research. METHODS: The cytotoxicity and anti BoHV-5RJ42/01 activity of a set of synthetic 4-oxoquinoline derivatives 4a-k were assayed on Madin-Darby Bovine Kidney cell and antiviral activity by plaque reduction assay. RESULTS: = 24 µM ±5.1) presented similar inhibitory profile and selectivity indexes of 1.4 and 2.9, respectively. The results of the time-of-addition studies revealed expressive reduction of virus production (≥80%) in different stages of virus replication cycle except for compound 4h that slightly inhibited virus yield in the first 2 h post infection, but it showed expressive virus inhibition after this time. CONCLUSIONS: All three compounds slightly interact with the virus on the virucidal assay and they are not able to block virus attachment and penetration. Antiviral effect of oxoquinoline 4h was more prominent than acyclovir which leads us to suggest compound 4h as a promising molecule for further anti-BoHV-5 drug design.
No takes yet. Share an insight, caveat, or question.
Pinto et al. (2019) studied Bovine Herpesvirus Type 5 infection. 4-oxoquinoline derivatives (compound 4h) vs. Acyclovir was evaluated on Reduction of virus production. The 4-oxoquinoline derivative 4h reduced Bovine Herpesvirus Type 5 production by ≥80% in vitro, demonstrating a more prominent antiviral effect than acyclovir.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: