Key result
A sub-anaesthetic dose of propofol administered at the end of surgery did not reduce the incidence of nausea and vomiting compared to normal saline.
Why the study?
Does a sub-anaesthetic dose of propofol prevent nausea and vomiting in patients undergoing gynaecological laparoscopy?
RCT (n=53)
Does a sub-anaesthetic dose of propofol prevent nausea and vomiting in patients undergoing gynaecological laparoscopy?
A sub-anaesthetic dose of propofol administered at the end of surgery does not have an anti-emetic effect in patients undergoing gynaecological laparoscopy.
No support for sub-anaesthetic propofol to prevent PONV in gynaecological laparoscopy; leaves open efficacy in RCTs.
In order to investigate the putative anti-emetic effect of propofol, 53 patients undergoing gynaecological laparoscopy were given a standard anaesthetic including induction with thiopentone. At the end of surgery, the patients received either a sub-anaesthetic does of propofol or an equivalent volume of normal saline. There was no difference in the incidence of nausea and vomiting between the propofol and control group. It is concluded that low-dose propofol does not have an anti-emetic effect.
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Campbell et al. (1991) conducted an RCT in Patients undergoing gynaecological laparoscopy (n=53). Propofol vs. Normal saline was evaluated on Incidence of nausea and vomiting. A sub-anaesthetic dose of propofol administered at the end of surgery did not reduce the incidence of nausea and vomiting compared to normal saline.
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