Key result
Computational simulations demonstrate that under conditions of flow-induced ATP release, the ATP + ADP concentration at the endothelial cell surface is considerably lower for a wavy cell surface than for a flat surface.
Population
Computational model of vascular endothelial cells in a parallel plate flow chamber
Comparison
Wavy endothelial cell surface topography with… vs Flat endothelial cell surface (h/k = 0)
Design
Preclinical
Authors
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Wavy endothelial surfaces may blunt flow-induced ATP signaling; leaves open mechanistic role in regional endothelial dysfunction.
Computational modeling demonstrates that endothelial cell waviness significantly lowers surface ATP and ADP concentrations under flow, potentially explaining impaired calcium signaling in regions of disturbed arterial flow.
Choi et al. (2009) studied Endothelial cell mechanotransduction (computational model). Cell surface waviness (undulations) vs. Flat cell surface was evaluated on ATP + ADP concentration at the endothelial cell surface. Computational simulations demonstrate that under conditions of flow-induced ATP release, the ATP + ADP concentration at the endothelial cell surface is considerably lower for a wavy cell surface than for a flat surface.
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