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May 1, 1991AJP Heart and Circulatory Physiology

Flow-induced changes in Ca2+ signaling of vascular endothelial cells: effect of shear stress and ATP

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Population

Cultured bovine aortic endothelial cells, calf pulmonary artery endothelial cells, and human umbilical vein…

Comparison

Hemodynamic flow in the presence of adenine… vs Hemodynamic flow in the absence of adenine…

Design

Preclinical

Authors

MMMinli MoChinese Academy of SciencesSES. G. EskinBaylor College of MedicineWSWilliam P. SchillingMetroHealth

Discussion

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Implication

Flow-dependent nucleotide effects on endothelial calcium are hypothesis-generating; should not change practice pending in vivo confirmation.

Structured PICO

P
Population
Cultured bovine aortic endothelial cells, calf pulmonary artery endothelial cells, and human umbilical vein endothelial cells
I
Intervention
Hemodynamic flow (shear stress) in the presence of adenine nucleotides (ATP, ADP, or AMP)
C
Comparator
Hemodynamic flow in the absence of adenine nucleotides, and zero-flow conditions
O
Outcome
Apparent cytosolic free Ca2+ concentration ([Ca2+]i)surrogate

Hemodynamic flow combined with adenine nucleotides significantly increases cytosolic calcium in vascular endothelial cells, suggesting a role for convective-diffusive transport of ATP in regulating blood flow.

Cite This Study

Mo et al. (1991) studied this question.

synapsesocial.com/papers/6a762bb4d5b06e2c1e614a0dhttps://doi.org/10.1152/ajpheart.1991.260.5.h1698
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Convective Mass Transfer Effects on the Intracellular Calcium Response of Endothelial Cells1992 · 55 citations
  2. 2Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells1992 · 349 citations
  3. 3Modulation of ATP/ADP Concentration at the Endothelial Cell Surface by Flow: Effect of Cell Topography2009 · 11 citations
  4. 4Calcium responses of endothelial cell monolayers subjected to pulsatile and steady laminar flow differ1995 · 138 citations
  5. 5ATP Release from Cultured Endothelial Cells and Intercellular Calcium Signaling during Shear Stress Exposure2009 · 2 citations