Key result
Platelet indices including mean platelet volume, platelet distribution width, and platelet large cell ratio were substantially greater in patients with acute coronary syndrome than in healthy controls.
Why the study?
Platelets influence coronary thrombus formation and atherosclerotic lesions, prompting the evaluation of the significance and role of platelet indices in acute coronary syndrome.
Do impedance-based platelet indices differ between patients with acute coronary syndrome and healthy controls?
Case-Control (n=200)
No
Do impedance-based platelet indices differ between patients with acute coronary syndrome and healthy controls?
Elevated platelet indices such as mean platelet volume and platelet distribution width are associated with acute coronary syndrome and may serve as accessible biomarkers for risk stratification.
Answers are grounded in this paper and cite their sources.
Suggests platelet indices may serve as accessible biomarkers for coronary artery disease risk; leaves open whether these.
Background: The primary cause of coronary artery disease is atherosclerosis and its complications. Formation of coronary thrombus and initiation of atherosclerotic lesions are significantly influenced by platelets and their activity. Compared to smaller platelets, giant platelets have a larger potential thrombotic ability and are more metabolically and enzymatically active.Aim: The objective of the current research is to determine the significance and role of platelet indices by comparing the values in patients with Acute Coronary Syndrome (ACS) to those in healthy controls.Materials and Methods: This prospective case-control study was carried out in a tertiary care centre with 100 cases and 100 controls for 6 months. Blood samples were taken when the patient was admitted. Platelet indices were measured within 30 minutes of blood collection using an automated haematology analyzer.Results: Platelet indices such as Mean platelet volume, Platelet distribution width and Platelet large cell ratio were substantially greater in patients with ACS than in healthy controls. Platelet count and Plateletcrit showed lower level in ACS patients with respect to controls.Conclusion: Platelet indices measurement would be beneficial in estimating those patients at greater risk for developing ACS in the future.
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Koppalkar et al. (2024) conducted a case-control in Acute Coronary Syndrome (n=200). Platelet indices vs. Healthy controls was evaluated on Platelet indices (Mean platelet volume, Platelet distribution width, Platelet large cell ratio, Platelet count, Plateletcrit). Platelet indices including mean platelet volume, platelet distribution width, and platelet large cell ratio were substantially greater in patients with acute coronary syndrome than in healthy controls.
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