Key result
Platelet volume indices discriminate ACS from stable angina but lack short-term prognostic utility.
Why the study?
Early diagnosis of ACS improves outcomes, but the diagnostic and prognostic value of platelet volume indices in ACS remains to be clarified.
Do platelet volume indices accurately diagnose acute coronary syndrome and predict ICU stay or in-hospital mortality?
Observational (n=638)
Do platelet volume indices accurately diagnose acute coronary syndrome and predict ICU stay or in-hospital mortality?
p-value: p=<0.001
Platelet volume indices can effectively discriminate acute coronary syndrome from stable angina as early diagnostic markers, but they lack short-term prognostic utility for ICU stay or in-hospital mortality.
Acute coronary syndrome (ACS) is a leading global cause of mortality, driven by platelet-mediated atherothrombosis; early diagnosis improves outcomes. This study aimed to evaluate platelet volume indices, including mean platelet volume (MPV), platelet distribution width (PDW), and platelet-large cell ratio (P-LCR), for ACS diagnosis and their prognostic value for ICU stay and in-hospital mortality. Prospective comparative study of 638 patients (381 ACS, 257 stable angina). Venous blood samples collected in EDTA tubes were analyzed for platelet count and indices within 30 minutes; 12-lead ECG and cardiac biomarkers were assessed. ICU stay and in-hospital mortality were recorded. Platelet volume indices were significantly higher in ACS patients with significant diagnostic accuracy for ACS (p-value: <0.001). Platelet counts were insignificantly lower in ACS patients (P-value: 0.189). No significant correlations between MPV, PDW, and P-LCR in ACS patients and their length of ICU stay (P-value: 0.387, 0.433, and 0.697) or incidence of in-hospital mortality (P-value: 0.125, 0.118, and 0.169), respectively. Platelet volume indices, inexpensive and widely available, effectively discriminate ACS from stable angina as early markers but lack short-term prognostic utility for ICU stay or mortality.
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Youssef et al. (2026) conducted an observational in Acute coronary syndrome (n=638). Platelet volume indices (MPV, PDW, P-LCR) vs. Stable angina was evaluated on Diagnostic accuracy for acute coronary syndrome (p=<0.001). Platelet volume indices effectively discriminated acute coronary syndrome from stable angina (P<0.001), but lacked short-term prognostic utility for ICU stay or in-hospital mortality.
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