Why the study?
Are platelet volume indices elevated in patients with acute coronary syndrome compared to healthy controls?
Are platelet volume indices elevated in patients with acute coronary syndrome compared to healthy controls?
Platelet volume indices are significantly elevated in patients with acute coronary syndrome compared to healthy controls, suggesting potential utility as a predictive biomarker.
May support platelet indices as ACS biomarkers; hypothesis-generating and requires prospective validation before clinical adoption.
Background: Acute coronary syndrome (ACS) is a set of signs and symptoms due to rupture of a plaque which are a consequence of platelet- rich coronary thrombus formation. The aim of study was to compare the platelet volume indices (PVI) in acute coronary syndrome with healthy controls.Methods: The study was carried out on 100 cases diagnosed with acute coronary syndrome and 50 controls from June 2012 to September 2014.Results: All platelet volume indices i.e. mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (PLCR) were significantly raised in patients with acute myocardial infarction (AMI) and unstable angina (UA), (MPV 9.2 fl, PDW 11.3 fl, PLCR 19.3 fl,) compared to those with control group (MPV 8.6 fl, PDW 10.2 fl, PLCR 15.8 fl).Conclusions: PVI are simple investigations that can be used for predicting impending acute cardiovascular events.
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Biradar et al. (2016) studied this question.
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