Key result
Patients with coronary artery disease had significantly higher mean platelet volume compared to healthy controls (12.34 vs 9.41, p<0.001), which decreased significantly after 7 days of treatment.
Why the study?
The study was conducted to delineate the relations between various platelet volume indices and their role in coronary heart disease.
Do platelet volume indices differ in patients with coronary artery disease compared to healthy controls, and do they change after treatment?
Population
180 subjects, including 120 CAD cases and 60 healthy controls
Comparison
ACS medically treated vs prior PCI vs healthy controls
Design
Case-control study
Authors
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Suggests mean platelet volume may serve as a dynamic biomarker in coronary artery disease; leaves open whether.
Observational (n=180)
No
Do platelet volume indices differ in patients with coronary artery disease compared to healthy controls, and do they change after treatment?
Absolute Event Rate: 12.34% vs 9.41%
p-value: p=<0.001
Platelet volume indices are significantly elevated in patients with coronary artery disease, decrease following treatment, and may serve as prognostic markers for in-hospital mortality.
Payal et al. (2021) conducted an observational in Coronary Artery Disease (n=180). Coronary Artery Disease vs. Healthy controls was evaluated on Mean Platelet Volume (MPV) (p=<0.001). Patients with coronary artery disease had significantly higher mean platelet volume compared to healthy controls (12.34 vs 9.41, p<0.001), which decreased significantly after 7 days of treatment.
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