Key result
Past year major depression was associated with an increased risk of incident ischemic heart disease in Chinese adults (HR 1.32; 95% CI 1.15-1.53).
Why the study?
Does past year major depression increase the risk of incident ischemic heart disease in Chinese adults?
Population
Over 0.5 million Chinese adults aged 30 to 79 years from the China Kadoorie Biobank study
Comparison
Past year major depression measured with the… vs Participants without major depression
Design
Cohort
Follow-up
Baseline until December 31, 2013
Authors
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Association warrants no practice change; leaves open whether depression treatment reduces ischemic heart disease risk in Chinese adults.
Cohort (n=500,000)
Yes
Does past year major depression increase the risk of incident ischemic heart disease in Chinese adults?
Hazard Ratio: 1.32 (95% CI 1.15–1.53)
Absolute Event Rate: 8.76% vs 7.21%
Past year major depression is independently associated with a 32% increased risk of incident ischemic heart disease in Chinese adults, with a stronger association observed in urban residents.
Liu et al. (2016) conducted a cohort in Ischemic heart disease (n=500,000). Major depression vs. No major depression was evaluated on Incident ischemic heart disease (IHD) (HR 1.32, 95% CI 1.15-1.53). Past year major depression was associated with an increased risk of incident ischemic heart disease in Chinese adults (HR 1.32; 95% CI 1.15-1.53).
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