Why the study?
Does the combination of epidural anesthesia and aprotinin reduce perioperative blood loss and transfusion requirements in patients undergoing total hip arthroplasty?
Population
60 patients undergoing total hip arthroplasty
Comparison
Epidural anesthesia combined with general… vs General anesthesia + placebo (equal volume)
Design
RCT, allocated randomly to four groups, double-blind
Follow-up
first 24 hours postoperatively
Authors
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Supports combined epidural anesthesia and aprotinin to minimize transfusions in total hip arthroplasty; extends RCT evidence for multimodal blood conservation.
Does the combination of epidural anesthesia and aprotinin reduce perioperative blood loss and transfusion requirements in patients undergoing total hip arthroplasty?
The combination of epidural anesthesia and aprotinin significantly reduces perioperative blood loss and transfusion requirements in total hip arthroplasty.
d'Ambrosio et al. (1999) studied this question.
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