Why the study?
Does aprotinin reduce total blood loss in patients undergoing bilateral or revision total hip arthroplasty?
Population
53 consecutive patients undergoing bilateral (bTHA) or revision total hip arthroplasty (rTHA)
Comparison
Aprotinin 3.8 x 10 Kallikrein inactivation units… vs Blinded placebo solution
Design
RCT, randomized, blinded solution
Follow-up
predischarge
Authors
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Supports selective use in high-bleed hip arthroplasty; confirms efficacy but questions routine adoption due to modest benefit.
Does aprotinin reduce total blood loss in patients undergoing bilateral or revision total hip arthroplasty?
Aprotinin reduces total blood loss in patients undergoing bilateral or revision total hip arthroplasty, though its routine use may not be justified by the slight reduction.
Murkin et al. (1995) studied this question.
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