Why the study?
Does oral ketamine provide similar sedation and safety compared to intramuscular morphine as premedication in children with congenital heart disease?
Does oral ketamine provide similar sedation and safety compared to intramuscular morphine as premedication in children with congenital heart disease?
Oral ketamine is a safe and effective alternative to intramuscular morphine for premedication in children undergoing cardiac surgery for congenital heart disease.
May support oral ketamine as alternative to IM morphine for premedication in pediatric CHD; leaves open confirmation in randomized trials.
In a single-blind controlled study, forty children with congenital heart disease were premedicated with oral trimeprazine 3 mg/kg and either intramuscular morphine 0.1 mg/kg or oral ketamine 10 mg/kg. Cardiovascular and respiratory effects of premedication and degree of sedation induced were similar in the two groups of patients. Oral ketamine is a safe and effective premedicant in this group of patients.
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STEWART et al. (1990) studied this question.
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