Key result
Oral midazolam premedication leaves 0 patients anxious on ward departure vs trimeprazine and placebo.
Why the study?
The effect of oral premedication with midazolam versus trimeprazine or placebo in children undergoing tonsillectomy and/or adenoidectomy was investigated to assess sedation and ease of induction.
Does oral midazolam improve sedation and ease of induction compared to trimeprazine or placebo in children undergoing tonsillectomy and/or adenoidectomy?
RCT (n=85)
Double-blind
Does oral midazolam improve sedation and ease of induction compared to trimeprazine or placebo in children undergoing tonsillectomy and/or adenoidectomy?
p-value: p=0.0007
Oral midazolam is an effective premedicant that significantly reduces anxiety and distress in children prior to surgery compared to trimeprazine or placebo.
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Oral midazolam 0.5 mg/kg provides reliable anxiolysis for pediatric tonsillectomy; confirms RCT superiority over trimeprazine or placebo for induction.
Mitchell et al. (1997) conducted an RCT in Tonsillectomy and/or adenoidectomy (n=85). Midazolam vs. Trimeprazine 2 mg.kg-1 given 90 min pre-operatively and placebo was evaluated on Anxious, crying or distressed on leaving the ward (p=0.0007). Oral midazolam premedication resulted in 0 patients being anxious or distressed on leaving the ward, compared to 2/28 with trimeprazine and 5/28 with placebo (p=0.0007).
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