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September 1, 1994Anaesthesia

Oral administration of midazolam as a premedicant for paediatric day‐case anaesthesia

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Why the study?

Does oral midazolam improve pre-operative anxiolysis in children aged 1-10 years scheduled for day-case anaesthesia?

Population

54 children aged 1-10 years, scheduled for day-case anaesthesia

Comparison

Oral midazolam 0.5 mg/kg administered 30-60… vs Placebo preparation administered 30-60 minutes…

Design

RCT, double-blind

Follow-up

2 weeks

Authors

AMA. McCluskeyUniversity of GlasgowGMG. MEAKINBoston Children's Hospital

Discussion

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Implication

Supports oral midazolam premedication for pediatric day-case anesthesia; confirms anxiolytic superiority versus placebo in RCT.

Structured PICO

Does oral midazolam improve pre-operative anxiolysis in children aged 1-10 years scheduled for day-case anaesthesia?

P
Population
54 children aged 1-10 years, scheduled for day-case anaesthesia
I
Intervention
Oral midazolam 0.5 mg/kg administered 30-60 minutes pre-operatively
C
Comparator
Placebo preparation administered 30-60 minutes pre-operatively
O
Outcome
Anxiolysis on arrival at the induction roompatient reported

Oral midazolam provides effective pre-operative anxiolysis and reduces postoperative behavioral disturbances in pediatric day-case anesthesia, despite slightly prolonging recovery and discharge times.

Cite This Study

McCluskey et al. (1994) studied this question.

synapsesocial.com/papers/6a7109e5febe604dd709c3fahttps://doi.org/10.1111/j.1365-2044.1994.tb04451.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oral Midazolam is an Effective Premedication for Children Having Day-Stay Anaesthesia1992 · 121 citations
  2. 2Oral Midazolam in Children1992 · 150 citations
  3. 3Intramuscular midazolam premedication in small children1986 · 46 citations
  4. 4RELATIONSHIP OF ANESTHESIA TO POSTOPERATIVE PERSONALITY CHANGES IN CHILDREN1953 · 166 citations