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May 1, 1997Pediatric Anesthesia

Oral premedication with midazolam in paediatric anaesthesia. Effects on sedation and gastric contents

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Why the study?

Does oral midazolam improve sedation and affect gastric contents in children undergoing paediatric anaesthesia?

Population

107 children, aged between 3 and 10 years, undergoing paediatric anaesthesia

Comparison

Midazolam 0.75 mg/kg by mouth vs Placebo (5 ml of water by mouth) or control group

Design

RCT, at random, double blind

Authors

JRJuan RivaUniversidad de la República de UruguayGLGladys LejbusiewiczUniversidad de MontevideoMPMERCEDES PAPASri Ramachandra Institute of Higher Education and Research

Discussion

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Implication

Supports oral midazolam as premedication in pediatric anesthesia; confirms sedation efficacy without altering gastric contents.

Structured PICO

Does oral midazolam improve sedation and affect gastric contents in children undergoing paediatric anaesthesia?

P
Population
107 children, aged between 3 and 10 years, undergoing paediatric anaesthesia
I
Intervention
Midazolam 0.75 mg/kg by mouth
C
Comparator
Placebo (5 ml of water by mouth) or control group
O
Outcome
Sedation, quality of induction, recovery time, acceptance, and effects on gastric contents (gastric pH and residual volume)

Oral midazolam is an effective and safe premedication for achieving sedation in pediatric anesthesia without adversely affecting gastric contents.

Cite This Study

Riva et al. (1997) studied this question.

synapsesocial.com/papers/6a802e0555fbe903add47005https://doi.org/10.1046/j.1460-9592.1997.d01-75.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oral administration of midazolam as a premedicant for paediatric day‐case anaesthesia1994 · 68 citations
  2. 2Oral midazolam premedication for paediatric day case patients1996 · 52 citations
  3. 3Oral Midazolam is an Effective Premedication for Children Having Day-Stay Anaesthesia1992 · 121 citations
  4. 4A study to determine the effectiveness of rectally administered Midazolam for premedication in children.2009 · 1 citations
  5. 5Midazolam for premedication in children: Nasal vs. rectal administration1997 · 39 citations