December 1, 1995The Journal of Clinical Pharmacology

Variability in the Pharmacokinetics and Pharmacodynamics of Low Dose Aspirin in Healthy Male Volunteers

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Population

10 healthy, young male subjects

Design

Other, open-label

Follow-up

24 hours after each dose

Authors

IBIrma H. BenedekEndo Pharmaceuticals (United States)AJAmita JoshiSunesis (United States)HPHenry J. PieniaszekMerck & Co., Inc., Rahway, NJ, USA (United States)

Discussion

Member takes

Implication

Variability in aspirin response in healthy volunteers warrants dosing caution; leaves open implications for efficacy in cardiovascular patients.

Structured PICO

Population

10 healthy, young male subjects

Intervention

Single, open-label, oral 80-mg aspirin dose on three separate days, each separated by a 2-week washout interval

Outcome

Rate and extent of oral absorption, intra- and inter-subject variability of aspirin pharmacokinetics, and platelet aggregation effects up to 24 hours post-dosesurrogate

Low-dose aspirin exhibits significant intra- and inter-subject variability in pharmacokinetics and platelet aggregation in healthy volunteers.

Cite This Study

Benedek et al. (1995) studied this question.

synapsesocial.com/papers/6a8fc33ee9b07e8956f37d24 https://doi.org/10.1002/j.1552-4604.1995.tb04044.x

Topics

Dual antiplatelet therapy

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Implication

Variability in aspirin response in healthy volunteers warrants dosing caution; leaves open implications for efficacy in cardiovascular patients.