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September 1, 2006Plastic & Reconstructive Surgery

Role of Adipokines in the Obesity???Inflammation Relationship: The Effect of Fat Removal

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Why the study?

Does fat removal by liposuction improve cardiovascular risk and vascular inflammatory markers in obese patients?

Population

Obese patients

Design

Review

Authors

KEKatherine EspositoGGGiovanni GiuglianoNSNicol Scuderi

Discussion

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Overview

May improve metabolic markers in obesity; hypothesis-generating from Level 5 evidence and requires prospective trials before clinical consideration.

Structured PICO

Does fat removal by liposuction improve cardiovascular risk and vascular inflammatory markers in obese patients?

P
Population
Obese patients
I
Intervention
Fat removal by liposuction
O
Outcome
Modification of cardiovascular risk and vascular inflammatory markerssurrogate

This review suggests that fat removal via liposuction may improve insulin resistance and vascular inflammation, thereby potentially reducing cardiovascular risk in obese patients.

Cite This Study

Esposito et al. (2006) studied this question.

synapsesocial.com/papers/6a8fd2e14de49b62f41fcff8https://doi.org/10.1097/01.prs.0000232281.49432.ce
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationships of generalized and regional adiposity to insulin sensitivity in men.1995 · 766 citations
  2. 2Tumor Necrosis Factor-α Inhibits Insulin’s Stimulating Effect on Glucose Uptake and Endothelium-Dependent Vasodilation in Humans2003 · 177 citations
  3. 3Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men2000 · 2,445 citations
  4. 4Glucose clamp technique: a method for quantifying insulin secretion and resistance.1979 · 7,485 citations
  5. 5Circulating Interleukin‐6 in Relation to Adiposity, Insulin Action, and Insulin Secretion2001 · 634 citations