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March 4, 2003Journal of Medical Virology

The most severe cytopathic effect and highest viral replication rate were observed in SK-N-SH neuronal cells, which also showed unique upregulation of the NGFR gene.

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Population

Three human cell lines: SK-N-SH, U373MG, and HEp-2

Comparison

Infection with enterovirus 71 4643 strain vs Comparison among the three infected cell lines

Design

Preclinical

Authors

YWYu‐Ye WenTCTsuey‐Yu ChangSCShur‐Tzu Chen

Discussion

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Overview

Hypothesis-generating for NGFR-mediated EV71 neurovirulence in neuronal models; human validation required before any clinical consideration.

Structured PICO

P
Population
Three human cell lines: SK-N-SH (neuroblastoma), U373MG (glioblastoma), and HEp-2 (larynx epidermoid carcinoma)
I
Intervention
Infection with enterovirus 71 4643 strain (isolate from Taiwan)
C
Comparator
Comparison among the three infected cell lines
O
Outcome
Virus-mediated cytopathic effect (CPE), viral replication rate, and presence of mature virionssurrogate

Enterovirus 71 exhibits strong tropism for neuronal cells, potentially mediated by the neuron growth factor receptor (NGFR), consistent with clinical observations of its neurological impact.

Cite This Study

Wen et al. (2003) studied this question.

synapsesocial.com/papers/6a8fd7b6a6182377cd1cb0ffhttps://doi.org/10.1002/jmv.10366
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differences in replication capacity between enterovirus 71 isolates obtained from patients with encephalitis and those obtained from patients with herpangina in Taiwan2006 · 46 citations
  2. 2Phenotypic and Genotypic Characteristics of Novel Mouse Cell Line (NIH/3T3)-Adapted Human Enterovirus 71 Strains (EV71:TLLm and EV71:TLLmv)2014 · 14 citations
  3. 3Pluripotent Human embryonic stem cell derived neural lineages for in vitro modelling of enterovirus 71 infection and therapy2016 · 6 citations
  4. 4Identification of Site-Specific Adaptations Conferring Increased Neural Cell Tropism during Human Enterovirus 71 Infection2012 · 101 citations
  5. 5Cell and tissue tropism of enterovirus 71 and other enteroviruses infections2014 · 73 citations