Population
Isolated human atrial cardiomyocytes
Design
Preclinical
Authors
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Explains enhanced volatile effects on cardiac Ca currents at hypothermia via solubility; leaves open human in vivo confirmation.
Inhibition of L-type calcium currents by halothane and sevoflurane is determined by their aqueous concentration, which is temperature-independent, explaining stronger effects at lower temperatures due to increased solubility.
Hüneke et al. (2004) studied this question.
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