Transferable Antibiotic Resistance Associated with an Outbreak of Shigellosis

Article1 December 1967Transferable Antibiotic Resistance Associated with an Outbreak of ShigellosisW. EDMUND FARRAR JR., M.D., F.A.C.P., LAWRENCE C. DEKLE, A.B.W. EDMUND FARRAR JR., M.D., F.A.C.P.Search for more papers by this author, LAWRENCE C. DEKLE, A.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-6-1208 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptShigellae resistant to multiple antibiotics were first encountered in Japan in 1955, shortly after the clinical use of streptomycin, tetracycline, and chloramphenicol became widespread in that country (1). Since this time many epidemics of shigellosis due to organisms resistant to these three antibiotics plus sulfonamides have occurred in Japan. This type of multiple drug resistance was found to be mediated by a cytoplasmic deoxyribonucleic acid (DNA) particle (R factor) that replicates independently of the host chromosome and can be transferred from cell to cell among various species of gram-negative bacilli (2). Since 1962 transferable antibiotic resistance has been demonstrated in...References1. KITAMOTOKASAIFUKAYAKAWASHIMA ONKA: Drug sensitivity of Shigella strains isolated in 1955. J. Jap. Ass. Infect. Dis. 30: 403, 1956. Google Scholar2. WATANABE T: Infective heredity of multiple drug resistance in bacteria. Bact. Rev. 27: 87, 1963. CrossrefMedlineGoogle Scholar3. DATTA N: Infectious drug resistance. Brit. Med. Bull. 21: 254, 1965. CrossrefMedlineGoogle Scholar4. KABINSCOHEN SAS: Resistance-transfer factor in Enterobacteriaceae. New Eng. J. Med. 275: 248, 1966. CrossrefMedlineGoogle Scholar5. SMITH DH: Salmonella with transferable drug resistance. Ibid., p. 625. Google Scholar6. SMITHARMOUR DHSE: Transferable R factors in enteric bacteria causing infection of the genito-urinary tract. Lancet 2: 15, 1966. CrossrefMedlineGoogle Scholar7. WATANABEFUKASAWA TT: "Resistance transfer factor," an episome in Enterobacteriaceae. Biochem. Biophys. Res. Commun. 3: 660, 1960. CrossrefGoogle Scholar8. DAVISMINGIOLI BDES: Mutants of Escherichia coli requiring methionine or vitamin B12. J. Bact. 60: 17, 1950. CrossrefMedlineGoogle Scholar9. ANDERSONLEWIS ESMJ: Drug resistance and its transfer in Salmonella typhimurium. Nature (London) 206: 579, 1965. CrossrefMedlineGoogle Scholar10. AKIBA T: [Mechanisms of development of resistance in Shigella] (Jap.), in Proceedings of the 15th General Meeting of the Japanese Medical Association, vol. 5, 1959, p. 299 (cited by Watanabe (2)). Google Scholar11. FALKOWCITARELLAWOHLHIETERWATANABE SRVJAT: The molecular nature of R-factors. J. Molec. Biol. 17: 102, 1966. CrossrefMedlineGoogle Scholar12. SALZMANKLEMM TCL: Transferable drug resistance (R-factor) in enterobacteria, in Proceedings of the Sixth Interscience Conference on Antimicrobial Agents and Chemotherapy, October 26-28, 1966, Philadelphia, Pa., p. 46. Google Scholar13. GILLHOOK FAEW: Salmonella strains with transferable antimicrobial resistance. JAMA 198: 1267, 1966. CrossrefMedlineGoogle Scholar14. HALTALINNELSON KCJD: In vitro susceptibility of shigellae to sodium sulfadiazine and to eight antibiotics. JAMA 193: 705, 1965. CrossrefMedlineGoogle Scholar15. HARDY AV: Studies of acute diarrheal diseases. X-C. Further observations on relative efficacy of sulfonamides in Shigella infections. Public Health Rep. 60: 1037, 1945. CrossrefMedlineGoogle Scholar16. GARFINKELMARTINWATTPAYNEMASONHARDY BTGMJFJRPAV: Antibiotics in acute bacillary dysentery: observations in 1408 cases with positive cultures. JAMA 151: 1157, 1953. CrossrefMedlineGoogle Scholar17. SALZMANSCHERMOSS TCCDR: Shigellae with transferable drug resistance: outbreak in a nursery for premature infants. J. Pediat. 71: 21, 1967. CrossrefMedlineGoogle Scholar18. WATSON CE: Infectious drug resistance in shigellae in Cape Town. S. Afr. Med. J. 41: 728, 1967. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: W. EDMUND FARRARJR., M.D., F.A.C.P.; LAWRENCE C. DEKLE, A.B.Affiliations: Atlanta, GeorgiaFrom the Department of Preventive Medicine and Community Health, Emory University School of Medicine, Atlanta, Ga.Requests for reprints should be addressed to W. Edmund Farrar, Jr., M.D., Department of Preventive Medicine, Emory University School of Medicine, 69 Butler St., SE, Atlanta, Ga. 30303. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntibiotic resistance of heterotrophic bacterial flora of two lakesShigella species from Addis Ababa: frequency of isolation and in vitro drug sensitivityAntibiotic Resistance in Intestinal BacteriaShigella Infection and Antibiotic ResistanceDAVID SCHLOSSBERG, M.D., JOHN E. MCGOWAN JR., M.D.Microbial Development of Drug Resistance: Mechanisms and Clinical SignificanceACTIVITY OF DISTAMYCIN A ON THE TRANSFER OF DRUG RESISTANCE IN GRAM-NEGATIVE CLINICAL ISOLATESInfectious Drug Resistance in BacteriaFrequency of R Factor-mediated Multiple Drug Resistance in Klebsiella and AerobacterBeta-lactamase of R factorsInfectious diseases. Annual review of significant publications. 1 December 1967Volume 67, Issue 6Page: 1208-1215KeywordsAntibiotic resistanceAntibioticsDrugsPrevention, policy, and public healthPreventive medicineShigellaShigellosisStreptomycinSulfonamideTetracyclines ePublished: 1 December 2008 Issue Published: 1 December 1967 PDF downloadLoading ...